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KMID : 0613820070170111511
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Journal of Life Science
2007 Volume.17 No. 11 p.1511 ~ p.1516
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Inhibitory Effects of Acanthopanax chiisanensis Ethanolic Extracts on FcεRI α Chain Expression
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Shim Sun-Yup
Sung Chan-Ki
Lee Sang-Won
Choi Young-Ju
Kim Hyeung-Rak
Byun Dae-Seok
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Abstract
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Basophils and mast cells play an important role in FcεRI-mediated allergic reaction as effector cells. We studied the effects of Acanthopanax chiisanensis on FcεRI α chain expression in human basophilic KU812F cells. Ethanol extracts from root and stem of A. chiisanensis were tested for inhibitory effects of FcεRI α chain expression. The cell surface FcεRI α chain expression was examined by flow cytometric analysis. All of the extracts of A. chiisanensis reduced the cell surface FcεRI α chain expression. Furthermore, A. chiisanensis extracts caused a decrease in the level of FcεRI α chain mRNA level and FcεRI-mediated histamine release. These results suggest that root and stem extracts of A. chiisanensis play an important role in anti-allergic activity via down-regulation of FcεRI α chain expression and decrease in release of inflammatory mediator such as histamine.
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KEYWORD
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Acanthopanax chiisanensis, FcεRI, histamine, KU812F
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